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From arthritis to lupus, sex and gender in rheumatology influence diagnosis and treatment
the authors emphasise how the systematic integration of sex and gender in rheumatology research and practice can improve diagnostic accuracy, treatment efficacy and equity of care, fostering the development of more representative studies and personalised treatment approaches
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Sex and gender approach for precision rheumatology
the need of going beyond the simple male/female pattern to achieve a real personalized medicine
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Immunometabolism in rheumatoid arthritis: mechanisms, biomarkers, and the path to precision medicine
high-dimensional biomarkers, such as blood-based metabolomic, transcriptomic, and proteomic signatures, and synovial molecular pathotypes can be used to stratify patients and predict how well biologic and targeted treatments will work.
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Advancing Toward the Precision Medicine in Rheumatoid Arthritis: Current Progress and Critical Challenges
Precision medicines approach for RA management is rapidly advancing, which offers potential shift from the traditional trial-and-error models toward treatment strategies that are more individualized, which consider each patient's unique molecular, genetic, and clinical profile.
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Proof-of-concept study demonstrates the feasibility of using high-content imaging to personalize RA treatment. It aligns with the broader trend of functional precision medicine, which has been successful in oncology. By evaluating drug effects on a cellular level, this approach may offer rheumatologists a new tool to tailor treatments and improve patient outcomes.
Current RA treatment relies largely on trial and error, with no reliable biomarkers to predict how a patient will respond to specific therapies. This study sought to address that gap by developing a high-throughput microscopy-based screening tool. The tool analyzes peripheral blood mononuclear cells (PBMCs) from patients with RA to quantify cell types, morphology, and interactions after exposure to various RA-specific drugs.
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Precision Medicine in Rheumatology: The Role of Biomarkers in Diagnosis and Treatment Optimization
Biomarkers are revolutionizing the management of rheumatic diseases by enhancing diagnosis, prognosis, and treatment personalization. Despite significant progress, their routine clinical application remains hindered by challenges related to validation, standardization, and clinical integration. The lack of universally accepted biomarker panels and standardized methodologies limits their widespread adoption.
Future research should prioritize harmonizing biomarker assessment protocols, conducting large-scale longitudinal studies, and integrating multi-omics data with artificial intelligence-driven predictive models.
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Precision Medicine in Rheumatoid Arthritis: New Frontiers
Advances in precision medicine and real-world evidence can guide clinicians in selecting therapies, improving outcomes for challenging RA cases. Enhanced biomarkers and clinical phenotyping may lead to earlier intervention and better disease management.
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A vision–language foundation model for
precision oncology
In this study, we present MUSK, a new vision–language foundation
model for general-purpose oncology applications. Through extensive
benchmark evaluation of 23 downstream tasks, we show that MUSK
achieves superior performance over existing foundation models, with
minimal or no further training, for applications in cancer detection,
diagnosis and grading.
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Quantum Surgical at the heart of a €23.9 million European project for precision cancer treatment
LThe PreciseOnco consortium aims to develop asuite of integrated technologies designed to take the next leap in precision cancer care. Central to the research and innovation program is spectral imaging, an advanced form of CT and cone-beam CT that captures significantly richer information about tissue composition than conventional imaging, enabling more confident differentiation between tumors, vasculature, and healthy tissue.
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Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project
The KPMP atlas provides molecular context for CKD and AKI disease drivers and will help define subtypes of disease that are not readily apparent from canonical functional or histopathologic characterization but instead are appreciable through advanced clinical phenotyping, pathomic, transcriptomic, proteomic, epigenomic, and metabolomic interrogation of kidney biopsy samples.
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I dagsläget finns fas 1-enheter inom onkologi på Sahlgrenska Universitetssjukhuset, Karolinska Universitetssjukhuset, Akademiska sjukhuset samt Skåne universitetssjukhus. Man kan argumentera/diskutera ifall digital twin studier kan ersätta nuvarande fas-1 studie ideer!
Det finns många fas 1-enheter i landet och patienterna räcker inte alltid till.
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Digital twins reveal patterns of breast cancer treatment resistance
Clinical trials can take years and are expensive. Creating digital twins can demonstrate outcomes for multiple treatment combinations, rapidly.
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UCL scientists design symbolic AI digital twins to treat cancer
The digital twins also suggested ways to help patients whose tumors had not responded well to treatment.
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From Simulation to Treatment: Advancing Tumor Therapy with Digital Twin Technology
Drug Development and Virtual Experimentation: Accurately simulate individualized biological processes and therapeutic responses to optimize drug screening, dosage adjustment and efficacy evaluation. Quantitative systems pharmacology models accurately predict the dose-response relationship, multi-omics integration models expand the capability of modeling tumor microenvironment, and cytokinetic simulations study the behavior of immune cells.
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From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling
Virtual patients for clinical trial simulation
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Researchers Find “Digital Twin” Model Accurately Predicts Treatment Responses for Different Chemotherapy Drugs
technology that is used by astrophysicists used to recreate clinical trials. The technology, FarrSight-Twin, uses algorithms to discover black holes, and the investigators found that it can create “digital twins” of real patients who have cancer to evaluate new treatments in clinical research.
From virtual to reality: innovative practices of digital twins in tumor therapy
Through international multi-center collaboration, a diverse and high-quality tumor data-sharing platform can be established to ensure the representativeness and adaptability of sample distributions.
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Precision medicine approach for preventing kidney failure
How type 5 collagen determines scarring severity
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Nephrogenomics, precision medicine and the role of genetic testing in adult kidney disease management
ClinVar, another NIH-supported endeavour, is a publicly accessible database that compiles information on genomic variation and its association with human health. ClinGen and ClinVar collaborate closely, fostering a partnership to enhance our understanding of clinically relevant genomic variations through shared data, archival efforts and collaborative curation. This partnership facilitates the characterization and dissemination of the clinical significance of genomic variations.
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Therapeutic Evolution in Gastroesophageal Adenocarcinoma Despite treatment advances and better outcomes, precision guidance still missing
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Targeting mitochondrial metabolism for precision medicine in cancer
not all studies applying ketogenic diet to cancer show a clear effect, suggesting that the type of cancer, genomic profile, as well as time and characteristics of the diet result in different outcomes. A combination of drug treatment and ketogenic diet may be an attractive approach to potentiate therapeutic response, as demonstrated in multiple clinical trials
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Genomic Medicine Sweden: Advancing precision medicine at the national level
Genomic Medicine Sweden (GMS) was established in 2017 as a national collaborative effort to accelerate implementation of genomics-based precision medicine within Sweden's regionally organized, publicly funded healthcare system.
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The microbiome in precision medicine
Deeper dive: Oncology
Emerging as the most active indication, oncology is ripe with microbiome innovation across diagnostics and drug discovery. The microbiome can carry signatures of cancer, making it well suited across the patient journey from early detection to diagnosis and monitoring.
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How scientists are rethinking genome sequencing to bolster precision medicine
Ultimately, the goal is to create a common foundation for genomic medicine to help ensure every patient benefits from the most accurate, consistent and reliable interpretation of their genome.
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Children's Hospital Colorado Delivers Precision Medicine to Kids
Integrating genomic diagnostics into day-to-day care
Children's Colorado formally took on the challenge in July 2023, when it established the Precision Medicine Institute, cofounded by Gaskell; Scott Demarest, MD, medical director; and Gregor Stoddard, administrative director. The institute delivers whole-genome sequencing data to clinical settings, conducts research, and generally leverages genomics to improve care.
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RNA Editing and Epitranscriptomics: Emerging Tools for Precision Medicine
the therapeutic market for epitranscriptomics is rapidly expanding, enabling the development of highly targeted interventions that alter RNA modifications implicated in disease. For example, inhibitors of the m6A 'writer' enzyme METTL3 have shown potential in preclinical models by disrupting oncogenic RNA methylation patterns, thereby impeding tumor growth.
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Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization
With advancements in medical research, traditional sequencing tools have become inadequate for meeting the evolving demands of modern research. Gene sequencing technology produces vast amounts of high-dimensional, sparse, and complex data. AI algorithms are frequently used to analyze and process these data
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Enhancer-based gene therapy: a new path for precision medicine
Enhancer-based gene therapy may be a path for precision medicine, particularly in the case of neurological diseases, cancer and other complex conditions. While there is potential to accomplish this goal, the effort faces many challenges including the need to understand the biology of enhancers and to solve the many technical and legal obstructions to applying this technique clinically.
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From resistance genes to resistance states: A transcriptomics-driven precision medicine framework for antimicrobial therapy
Precision medicine requires diagnostic tools that capture functional biological states rather than static markers alone. In the context of antimicrobial resistance, current diagnostics largely rely on phenotypic susceptibility testing or genomic detection of resistance determinants. While these approaches are indispensable, they provide limited insight into whether resistance mechanisms are actively engaged during infection or how bacterial responses evolve over the course of treatment. Transcriptomics offers an opportunity to complement existing diagnostics by enabling state-aware assessment of resistance pathways, potentially supporting more individualized antimicrobial decision-making.
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Digital twin model shows promise for predicting bone metastasis treatment response in prostate and renal cancers
These first-of-their-kind and spatially explicit, agent-based computational models – called A(BM)2 – include detailed information about the location and arrangement of cells within tumors, and simulate drivers of tumor progression, including blood vessel formation and bone resorption, based on in vivo data from prostate and kidney tumors..
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Transplantation immunology: paradigm shift from systemic suppression to microenvironment remodeling and precision modulation
.Deepened understanding of the alloimmune network has catalyzed a therapeutic revolution from “broad suppression” to “precision reconstruction.” Current trends are shifting from global immunosuppression toward precise modulation of specific cell subsets, signaling pathways, and local microenvironments.
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Circulating tumor DNA precision oncology enables effective and sensitive molecular diagnostics and actionable target detection in pediatric solid tumors - the INFORM experience
pan-cancer liquid biopsy study demonstrated the effectiveness of three NGS technologies in an orthogonal comparison, achieving a 92% technical success rate despite small sample volumes and low genetic redundancy.
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Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications
Enabled by the developments in nanotechnology, smart H2 delivery systems allow for controlled, targeted, and stimuli‐responsive H2 release, offering significant therapeutic potential in regulating immune‐related diseases..
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The world’s first digital cell twin in cancer electrophysiology: a digital revolution in cancer research?
With the first functional, non-phenomenological digital cell twins and their successors expected to exhibit higher levels of functional complexity, there is high potential to revolutionize modern cancer research through these new digital tools, which can range from single cell, to cell–cell interaction to 3D tissue models.
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From virtual to reality: innovative practices of digital twins in tumor therapy
.As technology advances and research deepens, DT technology has the potential to transition from the ‘‘virtual’’ to the ‘‘real,’’ becoming a critical tool in precision medicine and contributing to the global fight against cancer.
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Artificial Intelligence-Enabled Exosomes in Precision Oncology: A Framework for Clinical Utility and Biomedical Applications
Integrating AI into exosome research represents a watershed moment in precision oncology. Once dismissed as cellular waste, exosomes are now recognized as high-dimensional data carriers that capture the real-time evolution of the tumor microenvironment.
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Hybrid exosomes: a rising horizon for precision cancer therapy
Hybrid exosomes are being designed by combining with various nanoparticles to increase the efficiency and resolve the challenge associated with exosome-based cancer therapeutics like drug off-targeting.
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World Health Assembly endorses resolution on precision medicine
Precision medicine refers to the use of clinical, molecular, genomic and other health data to inform prevention, diagnosis and treatment, taking into account variability while applying appropriate ethical and legal safeguards.
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Precision Medicine Transformed Oncology —It’s Time to Do the Same for Sepsis
Harnessing the data to reignite innovation
It’s time we reignite treatment development for sepsis and other immune-mediated conditions that strike when patients are most vulnerable.
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Gene therapy offers new hope for telomere diseases
The therapy, called EXG-34217, uses a virus to deliver ZSCAN4 — a gene encoding a protein that extends telomeres — into the patient’s own stem cells. In two individuals, the therapy successfully lengthened telomeres and improved immune cell counts without causing major adverse side effects, pointing to EXG-34217 as a promising new therapy for TBD-related bone marrow failure.
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Mitochondria Closely Linked with Cancer Progression
Predictive modeling identified mtDNA copy number and the number of mitochondria-localized genes affected by mutations as the key predictors of expression of several cancer-associated hallmark pathways.
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Age-Based Genetic Testing Misses 72% of Patients with Inherited Cancer Variants
The findings challenge the longstanding assumption that inherited cancer predisposition is primarily a concern in patients diagnosed at unusually young ages and add to growing support for offering germline testing much more broadly to people with cancer.